High Blood Glucose: How to Interpret Elevated Results140–180 mg/dL (7.8–10.0 mmol/L) — interpretation depends on timing and context. A fasting value in this range exceeds the diabetes diagnostic threshold (≥126 mg/dL) and warrants prompt confirmatory testing. Post-meal readings here may occur after large, high-glycemic meals but cannot diagnose impaired glucose tolerance — that requires a standardized 75-g OGTT.
180–250 mg/dL (10.0–13.9 mmol/L) — clearly elevated. Persistent elevations warrant assessment using validated diagnostic tests. In hospitals, the ADA defines hyperglycemia as any glucose above 140 mg/dL, with persistent values ≥180 mg/dL on two occasions within 24 hours prompting treatment initiation.
If you are at risk of DKA, check ketones when symptoms or precipitating factors are present — particularly when glucose exceeds 200 mg/dL (11.1 mmol/L). This applies especially to people with type 1 diabetes, those who have missed insulin doses, anyone during acute illness, and people taking SGLT2 inhibitors, among whom euglycemic DKA (glucose below 200 mg/dL) is a recognized risk. DKA is confirmed by ketosis plus metabolic acidosis, not by the glucose number alone; glucose this high
with ketones and acidosis is a medical emergency.
Above 600 mg/dL (33.3 mmol/L) — possible HHS. A plasma glucose level of 600 mg/dL or higher may indicate hyperosmolar hyperglycemic state. Diagnosis also requires hyperosmolarity (effective serum osmolality >300 mOsm/kg or total serum osmolality >320 mOsm/kg), without significant ketonemia or acidosis. Suspected HHS is a medical emergency, especially in older adults with type 2 diabetes.
Causes of transient (non-diabetic) hyperglycemia: acute illness, surgery, trauma, pancreatitis, Cushing's syndrome, thyroid disorders, and medications (glucocorticoids, some antipsychotics).
Low Blood Glucose (Hypoglycemia): the International 3-Level ClassificationFor people on glucose-lowering therapy, hypoglycemia is defined as glucose
below 70 mg/dL (3.9 mmol/L) — the threshold where counter-regulatory responses activate, often before symptoms appear.
- Level 1 — 54–69 mg/dL (3.0–3.8 mmol/L): alert threshold. Treat immediately with ~15 g of fast-acting carbohydrate and recheck in 15 minutes (the "15-15 rule").
- Level 2 — below 54 mg/dL (below 3.0 mmol/L): clinically significant. Neuroglycopenic symptoms may begin: confusion, slurred speech, behavioral change. Repeated asymptomatic Level 2 episodes warrant evaluation for impaired hypoglycemia awareness — a single measurement does not establish it.
- Level 3 — any value: severe event. Altered mental or physical status requiring assistance from another person. For an unconscious person who cannot swallow safely: do not give food or drink — call emergency services and administer glucagon if available.
Early (adrenergic) symptoms: shakiness, sweating, rapid heartbeat, irritability, anxiety, intense hunger, tingling. Late (neuroglycopenic) symptoms: confusion, blurred vision, seizures, loss of consciousness.
Note: these thresholds and treatment rules apply to people receiving glucose-lowering therapy. In people without diabetes, clinically significant hypoglycemia is assessed by Whipple's triad: symptoms + a low measured glucose + relief of symptoms after glucose normalization.